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KMID : 0360220090500010051
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Journal of the Korean Ophthalmological Society
2009 Volume.50 No. 1 p.51 ~ p.60
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Short-term Efficacy of Intravitreal Bavacizumab for Polypoidal Choroidal Vasculopathy
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Lee Min-Ho
An Jin-Hwan
Lee Ji-Eun
Oum Boo-Sup
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Abstract
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Purpose: To evaluate the short-term effect of intravitreal bevacizumab (Avastinⓡ) in polypoidal choroidal vasculopathy.
Methods: Intravitreal Avastinⓡ was injected into 13 eyes of 13 patients with PCV in this retrospective, interventional case study. The follow-up period lasted over 3 months after therapy. Changes in best-corrected visual acuity (BCVA), foveal height determined by optical coherence tomography, and abnormal vasculature in indocyanine green angiography (ICGA) were evaluated.
Results: The mean LogMAR BCVA was 0.82 at baseline, 0.78 at 1 month after treatment, and 0.73 at 3 months after treatment. Visual acuity was stabilized or improved in 13 eyes (100%). The mean foveal height was 288 μm at baseline, 231 μm (p<0.05) at 1 month after treatment, and 196 μm at 3 months after treatment. The polypoidal lesions in ICGA decreased in 4 eyes (31%), although branching vasculature in ICGA was unchanged in 13 eyes (100%).
Conclusions: Intravitreal injection of Avastinⓡ may stabilize visual acuity and reduce macular edema due to decreased retinal pigment epithelial detachment and leaking. However, intravitreal injection had a minimal effect in occlusion of the symptomatic polypoidal lesions and no effect in occlusion of the branching vascular network.
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KEYWORD
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Bevacizumab, Polypoidal choroidal vasculopathy
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